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Target intelligence / Profile preview
Immune effector cell (via Fc receptor)
- Molecular classification
- Receptor
01
Overview
Immune effector cells, such as natural killer (NK) cells, macrophages, neutrophils, monocytes, and some B cells, mediate their functions through Fc receptors (FcRs). These receptors are critical for linking the humoral immune response—mediated by antibodies—to cellular immune responses. FcRs recognize the constant (Fc) region of antibodies that are bound to antigens on target cells or pathogens. Engagement of FcRs triggers downstream signaling pathways within effector cells, leading to processes like ADCC, ADCP, CDC and immunomodulation.
02
Mechanism of action
Binding of Fc region of antibody to Fc receptor on immune effector cells, triggering ADCC, ADCP, or CDC
03
Biological functions
Immune responseAntibody-dependent cellular cytotoxicity (ADCC)Antibody-dependent cellular phagocytosis (ADCP)Complement-dependent cytotoxicity (CDC)Immunomodulation
04
Disease associations
CancerInfectionInflammationAutoimmune diseases
05
Safety considerations
Cytokine release syndromeOff-target effectsImmunogenicityInflammation
06
Interacting drugs
Therapeutic antibodies
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