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Immune System: Induction of Tolerance

Molecular classification: Biological process, Functional pathway

Overview

Immune tolerance is a state in which the immune system does not mount a response to specific antigens that would otherwise provoke an immune reaction. This unresponsiveness can be naturally occurring (self-tolerance) or induced through deliberate intervention. The induction of immune tolerance is crucial for preventing autoimmunity, enabling successful organ transplantation, managing allergies, and maintaining homeostasis.

Mechanism of action

Various, including clonal deletion/apoptosis, anergy induction, and regulatory suppression by Tregs.

Biological functions

Immune regulationPrevention of autoimmunityMaintenance of immune homeostasisSuppression of immune responses

Disease associations

Autoimmune diseasesAllergiesTransplant rejectionCancer immune evasion

Safety considerations

Increased risk of infectionIncreased risk of cancerPotential for off-target effectsCompromised host defense capacity

Interacting drugs

Immunosuppressive drugs

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