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Target intelligence / Profile preview
Immune System (Allergic Response Modulation)
- Molecular classification
- Immune System Process, Signaling Pathway, Cytokine Signaling Pathway
01
Overview
The immune system's modulation of allergic responses involves a complex interplay between various immune cells, antibodies, and molecular pathways. Allergic reactions are hypersensitive immune responses to typically harmless antigens (allergens), resulting in symptoms ranging from mild irritation to severe anaphylaxis. The process is primarily mediated by immunoglobulin E (IgE) antibodies and involves both innate and adaptive immunity.
- Other names
- Allergic Response PathwayType I HypersensitivityAllergy SignalingIgE-mediated hypersensitivity
02
Mechanism of action
The mechanism of action depends on the specific drug, including: - Blocking histamine receptors - Reducing inflammation - Preventing mast cell degranulation - Neutralizing IgE - Blocking leukotriene receptors - Inducing immune tolerance to specific allergens
03
Biological functions
Immune ResponseInflammationAntibody ProductionCytokine ProductionMast cell degranulationAntigen presentation
04
Disease associations
Allergic RhinitisAsthmaEczemaFood AllergyAnaphylaxisInflammation
05
Safety considerations
Anaphylaxis (with allergen immunotherapy)Side effects of corticosteroids (immunosuppression, metabolic effects)Rebound effects upon withdrawal of certain medicationsPotential for serious infections with immunosuppressants
06
Interacting drugs
Antihistamines
6 more in the full profile.
07
Biomarkers
Total IgE levelsAllergen-specific IgE levelsEosinophil countMast cell mediators (histamine, tryptase)Cytokine profiles (IL-4, IL-5, IL-13)Skin prick test reactivityBasophil activation test
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