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Immune System (Broad Immunosuppression) (N/A)

Target: N/A
Molecular classification: Immune System Process, Biological System

Overview

Broad immunosuppression refers to the reduction or inhibition of the immune system’s activity as a whole. It is achieved through endogenous regulatory mechanisms or by exogenous agents such as drugs or pathogens. While essential for preventing excessive immune responses in autoimmune diseases and organ transplantation, it also increases susceptibility to infections and malignancies.

Other names: Broad ImmunosuppressionGlobal ImmunosuppressionGeneralized ImmunosuppressionSystemic Immunosuppression

Mechanism of action

Various mechanisms including inhibition of cytokine production, T cell activation, and lymphocyte proliferation.

Biological functions

Immune Response RegulationSelf-TolerancePrevention of Hyperinflammation

Disease associations

Autoimmune DiseasesOrgan Transplant RejectionHypersensitivity ReactionsIncreased Susceptibility to InfectionsIncreased Risk of Cancer

Safety considerations

Opportunistic InfectionsIncreased Cancer RiskImpaired Wound Healing

Interacting drugs

Cyclosporine A

4 more in the full profile.

Biomarkers

Immune cell counts (e.g., T cells, B cells)Cytokine levels (e.g., IL-10, TGF-β)Expression of inhibitory receptors (e.g., CTLA-4, PD-1)

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