Immune System (Desensitization to Phleum pratense Allergens) (N/A)

The immune system, in the context of desensitization to *Phleum pratense* (timothy grass) allergens, is the biological target for allergen immunotherapy. The goal is to modulate immune responses—specifically those that cause allergic reactions—to reduce or eliminate clinical symptoms upon exposure to grass pollen. Allergen immunotherapy introduces small, controlled doses of these allergens over time to induce immunologic tolerance by shifting the immune response away from a pathogenic Th2/IgE-dominated profile toward regulatory T cell activity and increased production of blocking antibodies such as IgG4. Key molecular players include allergen-specific IgE and IgG4, regulatory T cells, and major allergens like Phl p 1 & Phl p 5. Therapeutic approaches involve subcutaneous or sublingual administration of standardized *Phleum pratense* extracts.

Other names

Phleum pratense ImmunotherapyTimothy Grass Allergy DesensitizationGrass Pollen ImmunotherapyAllergen Immunotherapy (Phleum pratense)

Modulation of humoral and cellular immunity to induce tolerance to Phleum pratense allergens. Shift from Th2/IgE-mediated response to regulatory T cell activity and increased IgG4 production.