Target intelligence / Profile preview

Immune System (desensitization to timothy grass pollen)

Molecular classification
Immune system
01

Overview

Desensitization to timothy grass pollen targets the immune system, specifically aiming to reduce or eliminate allergic responses in individuals sensitized to this common environmental allergen. The process is achieved through allergen immunotherapy, which can be administered via subcutaneous injections (allergy shots) or sublingual tablets/extracts. The goal is to retrain the immune system so that it becomes tolerant of timothy grass pollen, thereby reducing symptoms of allergic rhinitis and asthma during pollen season.

02

Mechanism of action

Gradual reprogramming from allergic inflammation toward immune tolerance by introducing gradually increasing amounts of timothy grass pollen allergens, leading to reduced IgE production and increased regulatory T cell activity.

03

Biological functions

Modulation/tolerance induction against environmental allergensImmune toleranceRegulation of IgE productionRegulation of T cell activity
04

Disease associations

Allergic rhinitisAllergic conjunctivitisAsthma
05

Safety considerations

Requires frequent clinic visits (SCIT)Long-term efficacy may require continued therapyAllergic reactions to immunotherapy
06

Interacting drugs

Timothy grass pollen extract (Subcutaneous)

3 more in the full profile.

07

Biomarkers

Serum specific IgE antibodies (rPhl p 1, rPhl p 5)Regulatory T cell levelsFunctional antibody responses

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