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Immune System (Desensitization via Exposure to Phleum pratense Allergens)
- Molecular classification
- Allergen, Immune system
01
Overview
Desensitization to Phleum pratense allergens involves modulating the immune system's response to these allergens. It aims to shift the immune response from an IgE-mediated allergic reaction toward a more tolerogenic state. Key allergenic components include Phl p 1, Phl p 2, Phl p 4, Phl p 5, and Phl p 6. Immunotherapy leads to increased IgG4 antibodies and reduced immediate hypersensitivity. Administration can be via sublingual or subcutaneous routes, with the goal of reducing hay fever and asthma symptoms associated with grass pollen allergy.
- Other names
- Phleum pratense allergensTimothy grass pollen allergensPhl p 1, Phl p 2, Phl p 4, Phl p 5, Phl p 6 allergensGrass pollen allergens
02
Mechanism of action
Induction of immune tolerance via increased IgG4 and decreased IgE-mediated effector cell activation upon exposure to Phleum pratense allergens.
03
Biological functions
Immune responseAllergic reactionImmune tolerance induction
04
Disease associations
Allergic rhinitisAsthmaHay fever
05
Safety considerations
Local irritation at administration siteOral/nasal discomfort (sublingual immunotherapy)Injection site reactions (subcutaneous immunotherapy)Rare serious allergic reactions
06
Interacting drugs
Phleum pratense allergen extract (sublingual immunotherapy)
1 more in the full profile.
07
Biomarkers
Specific IgE levels (baseline and during therapy)Specific IgG4 levels (during therapy)Skin prick test reactivity
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