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Target intelligence / Profile preview
Immune System (IgE-Mediated Hypersensitivity)
- Molecular classification
- Immune System, Hypersensitivity Reaction
01
Overview
The immune system's role in eliciting IgE-mediated (Type I) hypersensitivity reactions. This involves sensitization to allergens, IgE production, mast cell activation, and the release of inflammatory mediators leading to allergic symptoms ranging from mild irritation to life-threatening anaphylaxis.
- Other names
- Type I HypersensitivityIgE-Mediated HypersensitivityAllergic Response
02
Mechanism of action
Varies depending on the drug; examples include blocking histamine receptors, inhibiting IgE binding, suppressing inflammation, stabilizing mast cells, and blocking leukotriene receptors.
03
Biological functions
Immune ResponseDefense against pathogensAllergic reactionInflammationAntibody productionMediator release
04
Disease associations
Allergic rhinitisAsthmaAnaphylaxisUrticariaEczemaFood allergiesAtopic dermatitisAllergic conjunctivitis
05
Safety considerations
AnaphylaxisImmunosuppression (with corticosteroids)Side effects of antihistamines (drowsiness, dry mouth)Injection site reactions (with Omalizumab)
06
Interacting drugs
Antihistamines
5 more in the full profile.
07
Biomarkers
Total IgE levelsAllergen-specific IgE levelsSkin prick test reactivityBasophil activation testEosinophil count
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