Immune system (induction of tolerance to Timothy grass pollen)

The immune system's induction of tolerance to Timothy grass pollen refers to the process by which immunological responses are modulated or suppressed, reducing allergic reactions in individuals sensitized to this specific allergen. This is primarily achieved through allergen-specific immunotherapy, which aims to desensitize the immune system and promote long-term tolerance. Immunotherapy works by repeated administration of small amounts of Timothy grass pollen extract—either sublingually or via injection—to shift the immune response away from Th2 dominance toward regulatory T cell (Treg) activity. This results in increased production of blocking IgG4 antibodies, reduced IgE levels over time, decreased activation/degranulation potential in mast cells/basophils, and overall clinical tolerance.

Other names

Timothy grass pollen allergyPhleum pratense allergyGrass pollen immunotherapy

Repeated administration of small amounts of Timothy grass pollen extract to shift the immune response away from Th2 dominance toward regulatory T cell (Treg) activity, resulting in increased production of blocking IgG4 antibodies, reduced IgE levels, and decreased activation/degranulation potential in mast cells/basophils.