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Target intelligence / Profile preview
Immune System (Overall) Modulation via Allergen Immunotherapy (AIT)
- Target
- AIT
- Molecular classification
- Immune system process, Multi-component biological process
01
Overview
Immune system desensitization via controlled allergen exposure (AIT) is a therapeutic approach that aims to reduce or eliminate allergic reactions by gradually exposing the immune system to increasing doses of specific allergens. This process induces long-term tolerance by modulating B and T cell responses, suppressing mast cell and basophil activation, and shifting the antibody profile from IgE to IgG4.
- Other names
- Allergen ImmunotherapyAllergen DesensitizationHyposensitizationAllergy ShotsSublingual ImmunotherapyOral Immunotherapy
02
Mechanism of action
Gradual exposure to increasing doses of allergen to shift immune response from IgE to IgG4 dominance, suppress mast cell/basophil activation, and induce regulatory T cells.
03
Biological functions
Immune tolerance inductionSuppression of allergic responseMast cell desensitizationB cell modulationT cell modulation
04
Disease associations
Allergic rhinitisAllergic conjunctivitisAllergic asthmaVenom allergyFood allergy
05
Safety considerations
Local allergic reactionsSystemic allergic reactions (urticaria, angioedema)AnaphylaxisExacerbation of asthmaEosinophilic esophagitis (with OIT)
06
Interacting drugs
Allergen extracts (various)
3 more in the full profile.
07
Biomarkers
Allergen-specific IgE levelsAllergen-specific IgG4 levelsRegulatory T cell (Treg) populationsCytokine profiles (IL-10, TGF-beta, IFN-gamma)Mast cell activation markers
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