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Immune System (Tolerance Induction via Exposure to Dermatophagoides pteronyssinus and Dermatophagoides farinae Allergens)
- Molecular classification
- Immune System Process, Tolerance Induction, Allergen Desensitization
01
Overview
The immune system can be modulated to induce tolerance to *Dermatophagoides pteronyssinus* and *Dermatophagoides farinae* allergens, shifting the immune response from an allergic state toward a regulatory state. This involves the induction of allergen-specific Tregs and B cells, production of immunosuppressive cytokines (IL-10, TGF-β), a shift in antibody profile (↑IgG4, ↓IgE), and a shift from Th2 to Th1/regulatory responses. Immunotherapy uses standardized extracts to harness these mechanisms, leading to reduced allergy symptoms upon re-exposure.
- Other names
- Allergen Immunotherapy (House Dust Mite)Dermatophagoides pteronyssinus/farinae ToleranceHouse Dust Mite ImmunotherapyHDM Tolerance
02
Mechanism of action
Induction of allergen-specific regulatory T cells (Tregs) and B cells; production of IL-10 and TGF-β; shift in antibody profile from IgE to IgG4 and IgA; shift from Th2 to Th1/regulatory immune responses.
03
Biological functions
Immune response modulationTolerance inductionSuppression of allergic inflammationRegulation of IgE productionInduction of regulatory T cellsShifting Th cell balance
04
Disease associations
Allergic rhinitisAsthmaAtopic dermatitisHouse dust mite allergy
05
Safety considerations
AnaphylaxisLocal reactions (swelling, itching)Exacerbation of allergic symptomsVariability in allergen extract potency and composition
06
Interacting drugs
Dermatophagoides pteronyssinus extract
2 more in the full profile.
07
Biomarkers
Allergen-specific IgE levelsAllergen-specific IgG4 levelsRegulatory T cell frequency (FoxP3+)IL-10 productionTGF-β productionBasophil activationEosinophil count
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