Target intelligence / Profile preview

Immune System (via Matrix-M Adjuvant) (N/A)

Target: N/A
Molecular classification: Adjuvant, Nanoparticle, Immunostimulant

Overview

Matrix-M is a vaccine adjuvant technology that enhances both innate and adaptive immune responses when co-administered with vaccine antigens. It consists of nanoparticles made from saponins, cholesterol, and phospholipids, and acts by recruiting and activating various immune cells, inducing cytokine production, and promoting robust B-cell and T-cell responses. It is used in several licensed vaccines developed by Novavax.

Other names: Matrix-M AdjuvantISCOMs (Immune Stimulating Complexes)Saponin-based AdjuvantQuillaja saponaria Adjuvant

Mechanism of action

Recruitment and activation of immune cells (monocytes, DCs, neutrophils, T-cells, B-cells, NK-cells) at the injection site and draining lymph nodes; Upregulation of activation markers on immune cells; Induction of cytokine production; Enhancement of antibody and cellular immunity.

Biological functions

Immune response enhancementAntigen presentationCytokine inductionB-cell activationT-cell activationInnate immune activationAdaptive immune activationImmunological memory formation

Disease associations

Infection (vaccine adjuvant to prevent infectious diseases)

Safety considerations

Local reactogenicity (injection site reactions)Systemic cytokine release (at high doses)

Interacting drugs

Vaccine antigens

Beyond the preview

Go deeper on Immune System (via Matrix-M Adjuvant) (N/A).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Immune System (via Matrix-M Adjuvant) (N/A).

Explore the full profile