Immunoglobulin E (human) (IgE)

Immunoglobulin E (IgE) is a glycosylated antibody class present in low concentrations in human serum and tissues. It is produced by plasma cells and plays a central role in triggering allergic responses by binding to high-affinity Fc epsilon RI on mast cells and basophils, leading to rapid release of histamine and other mediators upon allergen exposure. IgE is also involved in the immune defense against parasitic infections. Serum levels of IgE, and specific IgE antibodies, are key biomarkers in allergic disease diagnosis and monitoring. Therapeutic approaches in allergy often involve monoclonal antibodies that bind to soluble IgE, preventing its interaction with cell surface receptors and thus ameliorating allergic symptoms[5][1][3][4]. If you meant "soluble IgE receptor," canonical targets would be "Fc epsilon RI (high-affinity IgE receptor)" or "CD23 (low-affinity IgE receptor)"—both of which have soluble forms with distinct functions[2][4]. If clarification is needed (e.g., if you meant a specific soluble receptor), please specify for more targeted information.

Other names

IgEImmunoglobulin EHuman IgE

Neutralization of circulating IgE by monoclonal antibody, preventing IgE from binding Fc epsilon RI and CD23, thus blocking mast cell/basophil activation[5] Downregulation of IgE receptors (by lowering free IgE levels)