Immunoglobulin heavy variable (II)-65-1 (IGHVII-65-1)

Immunoglobulin heavy variable (II)-65-1 (IGHVII-65-1) is a pseudogene in the human immunoglobulin heavy chain variable region locus. Pseudogenes are non-functional derivatives of genes that have lost their protein-coding ability or are otherwise defective—they are not transcribed into functional proteins and therefore do not contribute directly to immune responses or therapeutic targeting. IGHVII-65-1 is listed as a pseudogene in genetic databases and does not encode an active part of the immunoglobulin (antibody) protein family, which are critical to adaptive immunity for recognizing diverse antigens[2][3][8]. This gene is not a therapeutic target since it is a pseudogene and does not produce a functional protein[2][3]. There are no known drugs, disease associations, or biomarker roles linked with this gene; it is significant mainly for genetic and evolutionary studies of the immunoglobulin gene family[8]. The locus is located in the human IGH cluster on chromosome 14q32.33[8].

Other names

IGHV(II)-65-14-65.1PIGHVII651IGHVII-65-1