Immunoglobulin heavy variable (III)-67-2 (IGHVIII-67-2)

Immunoglobulin heavy variable (III)-67-2 (IGHVIII-67-2) is a genomic segment classified as a pseudogene within the immunoglobulin heavy chain variable region locus on chromosome 14q32.33[2][4]. The immunoglobulin heavy chain locus comprises numerous variable (V), diversity (D), and joining (J) segments, which recombine to create functional antigen-binding sites on antibodies, mediating adaptive immunity[1][6]. However, many gene segments in this locus are pseudogenes; they carry sequence similarity to functional immunoglobulin genes but are non-functional due to mutations or deletions, and do not encode protein products. IGHVIII-67-2 falls into this category, meaning it does not contribute to the diversity of antibodies or encode a receptor protein that might serve as a drug target.

Other names

IGHV(III)-67-2IGHVIII-67-23-67.2PIGHVIII672