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Immunoglobulin heavy variable 1-67 (IGHV1-67) is classified as a pseudogene within the immunoglobulin heavy variable (IGHV) locus on chromosome 14. The IGHV region encodes the variable domains of the antibody heavy chain, which are critical for antigen recognition and immune response diversity[1][3]. While the IGHV locus overall is highly polymorphic and functionally impacts antibody repertoires and adaptive immunity, IGHV1-67 itself is a non-functional pseudogene according to standard genetic databases and major catalogs of IGHV genes[2]. Pseudogenes like IGHV1-67 do not code for functional protein products, do not undergo productive V(D)J recombination, and are not considered therapeutic targets or receptors.
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