Immunoglobulin heavy variable 3-63 (pseudogene) (IGHV3-63)

Immunoglobulin heavy variable 3-63 (IGHV3-63) is classified as a pseudogene located within the immunoglobulin heavy chain locus on chromosome 14. Like other members of the IGHV family, functional IGHV genes encode the variable region of the heavy chain in immunoglobulins (antibodies), which is critical for antigen recognition and adaptive immune response. However, as a pseudogene, IGHV3-63 is not transcribed into a functional protein and does not participate directly in antibody synthesis or immune function[3][6][7]. The presence of such pseudogenes reflects the evolutionary history and diversification of the immunoglobulin gene superfamily, but they are not considered actionable targets for drugs or therapeutics. IGHV3-63 is not a functional immunoglobulin variable gene but is annotated as a pseudogene in multiple genomic and biomedical information systems; hence it is not a therapeutic target or biomarker[3][6][7].

Other names

IGHV363V3-63PIGHV3-63 (pseudogene)