Immunoglobulin kappa variable 1-37 (non-functional) (IGKV1-37)

Immunoglobulin kappa variable 1-37 (non-functional) is a protein coded by the IGKV1-37 gene in humans. It encodes the variable domain of the immunoglobulin kappa light chain, but is considered a probable non-functional open reading frame: it is unlikely to produce a functional protein due to alterations affecting recombination sites or conserved regions[2][10]. While functional immunoglobulin variable chains are crucial for antigen recognition and the immune response, IGKV1-37 is not believed to be expressed as a productive immunoglobulin chain. According to multiple genomic and protein databases, the gene is predicted to be involved in immune response and to be located in the extracellular region or plasma membrane, as part of immunoglobulin complexes[2][4][9]. However, due to its non-functional status, it does not serve as a therapeutic target, disease marker, or drug interaction partner. **Key points:** - IGKV1-37 is a non-functional immunoglobulin kappa variable gene segment, and thus not a therapeutic target or biomarker. - No direct disease associations, drug interactions, or safety concerns are documented. - It is included in expression datasets, but without evidence of clinical or therapeutic relevance[3][7]. - All supporting information is consistent across authoritative genetics and protein databases[2][3][4][7][9][10].

Other names

IGKV137IGKV1-37O14Probable non-functional immunoglobulin kappa variable 1-37