Immunoglobulin kappa variable 1D-37 (non-functional) (IGKV1D-37)

Immunoglobulin kappa variable 1D-37 (IGKV1D-37) is a probable non-functional open reading frame (ORF) located in the variable region of the immunoglobulin kappa light chain locus. It is classified as "non-functional" because it cannot participate in productive immunoglobulin chain synthesis due to genetic defects such as altered V-(D)-J recombination, abnormal mRNA splicing, or critical amino acid changes. While functional immunoglobulin variable genes contribute to antibody diversity and immune response, IGKV1D-37 does not encode a productive protein and is typically regarded as an immunogenetic relic, not a therapeutic target or disease biomarker[1][3].

Other names

IGKV1D-37IGKV1D37O4Probable non-functional immunoglobulin kappa variable 1D-37