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Immunoglobulin kappa variable 2D-38 (IGKV2D-38) is classified as a **pseudogene** in the human genome; it does not encode a functional protein product[8][3][6]. While the gene belongs to the family of immunoglobulin kappa variable (IGKV) genes that contribute by V-(D)-J rearrangement to the vast diversity of antigen recognition in functional immunoglobulins[2][4], IGKV2D-38 itself is non-coding and not expressed as part of mature antibodies. Consequently, it does not serve as a therapeutic or functional receptor, enzyme, or transporter, nor does it have a role in disease biology, drug targeting, or biomarker utility. The presence of the "pseudogene" label in major genomic resources such as GeneCards and commercial suppliers confirms its non-functional status[8][3][6].
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