Immunoglobulin lambda variable (VI)-22-1 (IGLV(VI)-22-1)

Immunoglobulin lambda variable (VI)-22-1 encodes a variable region of the lambda light chain of immunoglobulins (antibodies)[5][3]. This domain contributes to antigen recognition and binding, forming part of the antigen-specific binding site together with the variable region of the heavy chain[2][3]. The lambda light chain is encoded at chromosome 22q11.2 and comprises multiple variable region genes with distinct subgroups[5][1]. Antibodies are composed of two heavy and two light chains (in humans, either kappa or lambda type), and each B cell expresses only one light chain class[3][1]. The immunoglobulin variable regions are generated by somatic recombination and hypermutation, ensuring immune diversity and specificity[1][3]. Lambda light chains, including the variable region encoded by IGLV(VI)-22-1, are important in both normal immune function and in disease contexts such as lymphoid malignancies and plasma cell dyscrasia, where changes in their expression are clinically relevant[3][1].

Other names

Immunoglobulin lambda variable VI-22-1IGLV(VI)-22-1Lambda variable VI-22-1IGLV