Immunoglobulin lambda variable 3-15 (pseudogene) (IGLV3-15)

Immunoglobulin lambda variable 3-15 (IGLV3-15) is classified as a pseudogene within the immunoglobulin lambda variable gene family, located on chromosome 22q11.2. Pseudogenes like IGLV3-15 are genomic sequences similar to functional genes but are generally non-functional and do not produce active protein products. The immunoglobulin lambda variable gene family encodes the variable regions of immunoglobulin light chains, which are critical for antigen recognition and adaptive immune responses, but IGLV3-15 itself does not encode a functional immunoglobulin domain due to its pseudogene status. IGLV3-15 is consistently listed as a pseudogene in major gene databases and references, indicated by sources such as Sigma-Aldrich, BioGPS, VarSome, and Merck Millipore. Pseudogenes do not encode functional proteins and thus are not considered therapeutic targets, diagnostic biomarkers, or direct participants in disease pathways. No evidence supports its use as a drug target or clinical biomarker; it does not interact with drugs or have a known mechanism of therapeutic action. The presence of this gene in nomenclature tables and genetic maps (e.g., IMGT) is for genomic annotation and does not imply functional significance. The aliases listed are alternate gene symbol forms or legacy nomenclature. There is nothing to suggest this entry is misspelled or a non-existent gene; however, it is important to note it is a pseudogene and not a functional protein-coding gene, so using it as a target is scientifically incorrect.

Other names

IGLV315V2-10PIGLV3-15