Immunologic Cytotoxicity (T Lymphocyte Replacement) (CTL Replacement)

Immunologic cytotoxicity, specifically T lymphocyte replacement, is a therapeutic strategy aimed at restoring or enhancing the cytotoxic activity of T lymphocytes (CTLs) in individuals with compromised immune function. This involves introducing functional CTLs into the patient to target and eliminate infected, cancerous, or otherwise abnormal cells. This approach is crucial for controlling viral infections, treating cancer, and managing post-transplant complications.

Other names

Cytotoxic T Lymphocyte ReplacementCTL TherapyT Cell ImmunotherapyAdoptive T Cell Therapy

Replacement of deficient or dysfunctional cytotoxic T lymphocytes with functional CTLs, leading to targeted killing of infected or malignant cells via granule exocytosis (perforin/granzymes) and Fas-FasL interaction.