Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Indoleamine 2,3-dioxygenase (None)
- Target
- None
- Molecular classification
- Enzyme, Dioxygenase, Heme-containing enzyme
01
Overview
Indoleamine 2,3-dioxygenase (IDO) is a cytosolic, heme-containing enzyme that catalyzes the initial and rate-limiting step in the degradation of the essential amino acid tryptophan along the kynurenine pathway. It plays a critical role in immune regulation by depleting local tryptophan levels and generating immunomodulatory kynurenines. IDO is a therapeutic target in cancer, autoimmune diseases, and transplantation due to its role in suppressing T cell activity.
- Other names
- IDOINDO
02
Mechanism of action
Inhibition of indoleamine 2,3-dioxygenase activity, leading to increased tryptophan levels and decreased kynurenine production, thereby promoting T cell activation and anti-tumor immunity.
03
Biological functions
Tryptophan catabolismImmune regulationAntimicrobial defenseT cell suppressionKynurenine pathway activation
04
Disease associations
CancerAutoimmune diseasesInfectionPregnancy complicationsTransplantation rejection
05
Safety considerations
Potential for immune-related adverse eventsUnintended effects on other tryptophan metabolic pathwaysDevelopment of resistance mechanisms in tumors
06
Interacting drugs
IDO inhibitors (e.g., epacadostat, navoximod)
2 more in the full profile.
07
Biomarkers
Kynurenine/tryptophan ratioIDO expression levels in tumor tissueIDO activity in serum
Beyond the preview
Go deeper on Indoleamine 2,3-dioxygenase (None).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Indoleamine 2,3-dioxygenase (None).