Inflammation Pathway (Non-Prostaglandin Mediated)

The inflammation pathway (non-prostaglandin mediated) refers to the complex network of cellular and molecular events involved in the inflammatory response, excluding those directly reliant on prostaglandin synthesis. This pathway involves cytokines (e.g., IL-1, TNF-α, IL-6), chemokines (e.g., CXCL8, CCL2), the complement system, kinins, nitric oxide, reactive oxygen species, and intracellular signaling cascades like NF-κB, MAPK, and JAK/STAT. Receptors such as TLRs, CLRs, and NLRs recognize pathogens and activate downstream signaling. Resolution of inflammation is crucial for tissue homeostasis and involves mediators like lipoxins, resolvins, and protectins.

Other names

Non-prostaglandin inflammatory cascadeInflammation mediated by cytokines, chemokines, and complementInflammation without prostaglandins