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The inflammatory cascade refers to a complex series of cellular and molecular events initiated in response to infection, injury, or other harmful stimuli. At the cellular membrane level, this cascade is primarily triggered by the recognition of pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) by specific membrane-bound receptors. This recognition leads to intracellular signaling that orchestrates the recruitment and activation of immune cells, production of inflammatory mediators, and ultimately tissue repair or resolution—or in pathological cases, chronic inflammation.
Varies depending on the specific target within the cascade; generally involves blocking receptor activation, inhibiting downstream signaling, or reducing cytokine production.
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