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Target intelligence / Profile preview
Inflammatory Response Modulation Pathway (Anti-inflammatory) (N/A)
- Target
- N/A
- Molecular classification
- Pathway, Signaling cascade, Regulatory network
01
Overview
The inflammatory response modulation pathway (anti-inflammatory) is a complex network of molecular and cellular mechanisms that downregulate and resolve inflammation, restoring tissue homeostasis after an immune challenge. It involves various anti-inflammatory cytokines (IL-10, TGF-β, IL-4), nuclear receptors (PPARγ), and neuroimmune circuits like the cholinergic anti-inflammatory pathway. Dysregulation of this pathway can contribute to chronic inflammatory diseases, highlighting its importance in maintaining immune balance.
- Other names
- Anti-inflammatory pathwayResolution of inflammation pathwayImmune homeostasis pathway
02
Mechanism of action
Multiple mechanisms, including: - Suppression of pro-inflammatory transcription factors (e.g., NF-kB, AP-1) - Activation of anti-inflammatory transcription factors (e.g., PPARγ) - Release of anti-inflammatory cytokines (e.g., IL-10, TGF-β) - Neuroimmune modulation via cholinergic signaling
03
Biological functions
Immune regulationTissue homeostasisInflammation resolutionNegative regulation of inflammatory response
04
Disease associations
Resolution of inflammationPrevention of chronic inflammationAutoimmune diseaseCardiovascular diseaseDiabetesOther Inflammatory Diseases
05
Safety considerations
Potential for immunosuppressionIncreased risk of infectionOff-target effects of drugs targeting specific components of the pathwayDysregulation leading to impaired wound healing
06
Interacting drugs
PPARγ agonists (e.g., thiazolidinediones)
3 more in the full profile.
07
Biomarkers
Levels of anti-inflammatory cytokines (e.g., IL-10, TGF-β) in serum or tissuesExpression levels of PPARγ in immune cellsVagal tone (heart rate variability)Resolution phase lipid mediators (e.g. resolvins, lipoxins)
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