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Target intelligence / Profile preview
Influenza A Virus Hemagglutinin (Stem Region) (HA Stem)
- Target
- HA Stem
- Molecular classification
- Class I Viral Fusion Protein, Viral Surface Glycoprotein
01
Overview
The stem region of the Influenza A virus hemagglutinin (HA) protein is a highly conserved domain that mediates fusion of the viral and host cell membranes, enabling viral entry. It is a key target for broadly neutralizing antibodies (bNAbs) and a focus for universal influenza vaccine development due to its conservation across different influenza subtypes.
- Other names
- Hemagglutinin StemHA2 subunitHemagglutinin stalkHA Stem RegionInfluenza A Virus Hemagglutinin (Stalk Region)
02
Mechanism of action
Inhibition of membrane fusion
03
Biological functions
Membrane fusionViral entryReceptor binding (indirectly, via HA1)pH-triggered conformational change
04
Disease associations
InfectionInfluenza
05
Safety considerations
Potential for off-target effects if antibodies cross-react with host proteinsRisk of antibody-dependent enhancement (ADE) of infection
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