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Target intelligence / Profile preview
Influenza A virus neuraminidase (N1) (N1)
- Target
- N1
- Molecular classification
- Enzyme
01
Overview
Influenza A virus neuraminidase N1 is a tetrameric surface glycoprotein enzyme belonging to group 1 NA subtypes, featuring a globular head domain with a conserved active site formed by eight inner shell residues (Arg118, Asp151, Arg152, Arg224, Glu276, Arg292, Arg371, Tyr406) that directly interact with sialic acid substrates and framework residues for structural stability. It includes a flexible 150-loop (residues 147-152) creating an additional cavity adjacent to the active site, calcium-binding sites for stability, and N-linked glycosylation sites. N1 cleaves terminal sialic acids from viral and cellular glycoconjugates, enabling virion release from host cells, preventing aggregation via hemagglutinin-sialic acid interactions, and facilitating virus penetration through respiratory mucins during infection.
- Other names
- NeuraminidaseNAsialidase
02
Mechanism of action
Competitive inhibition of sialic acid cleavage by mimicking transition state of hydrolysis
03
Biological functions
Cleavage of terminal sialic acid residues from glycoconjugatesFacilitation of viral release from infected cellsPrevention of viral aggregationCleavage of sialic acids from mucins to aid viral movement to target cells
04
Disease associations
Infection
05
Safety considerations
Resistance due to mutations in active site residues
06
Interacting drugs
Zanamivir
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