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Target intelligence / Profile preview
Influenza A virus neuraminidase protein (N9) (N9)
- Target
- N9
- Molecular classification
- Enzyme, Viral protein, Glycoprotein
01
Overview
The neuraminidase (NA) protein of Influenza A virus, specifically the N9 subtype, is a surface glycoprotein critical for viral replication and spread. It functions as an enzyme that cleaves terminal sialic acid residues from host cell glycans, facilitating the release of newly formed virions from infected cells and preventing viral aggregation. NA is a validated antiviral drug target, with inhibitors like oseltamivir and zanamivir blocking its enzymatic activity.
- Other names
- NANeuraminidaseInfluenza A Neuraminidase
02
Mechanism of action
Inhibition of neuraminidase enzymatic activity, preventing virion release and spread.
03
Biological functions
Viral replicationVirion releaseViral spreadSialic acid cleavage
04
Disease associations
InfectionInfluenza
05
Safety considerations
Drug resistance (e.g., H274Y mutation)Potential for mutations affecting drug binding and efficacy
06
Interacting drugs
Zanamivir
3 more in the full profile.
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