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Target intelligence / Profile preview
Influenza B Hemagglutinin (Yamagata Lineage) (HA)
- Target
- HA
- Molecular classification
- Viral protein, Glycoprotein, Class I viral fusion protein, Antigen
01
Overview
The hemagglutinin (HA) antigen of the Influenza B virus (Yamagata lineage) is a surface glycoprotein responsible for viral entry. It binds to sialic acid receptors on host cells and mediates membrane fusion. HA is a major target for neutralizing antibodies and is a key component of influenza vaccines.
- Other names
- HemagglutininInfluenza B HAB/Yamagata HA
02
Mechanism of action
HA mediates viral entry into host cells. Vaccines stimulate the production of neutralizing antibodies against HA, preventing viral attachment and fusion.
03
Biological functions
Viral attachmentMembrane fusionReceptor bindingImmune response
04
Disease associations
InfectionInfluenza
05
Safety considerations
Antigenic drift can lead to vaccine mismatch.Potential for antibody-dependent enhancement (ADE), though less likely with influenza B than A
06
Interacting drugs
NA inhibitors (e.g., Oseltamivir, Zanamivir) - indirectly, by preventing viral release
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