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Target intelligence / Profile preview
Influenza Virus Hemagglutinin Protein (Seasonal Strains) (HA)
- Target
- HA
- Molecular classification
- Glycoprotein, Viral protein, Surface antigen
01
Overview
The influenza virus hemagglutinin (HA) protein is a trimeric glycoprotein found on the surface of influenza viruses, including seasonal strains. It mediates viral attachment to host cells and fusion of the viral envelope with the host cell membrane. HA is a major target for neutralizing antibodies, and its high variability due to antigenic drift and shift necessitates regular updates to seasonal flu vaccines.
- Other names
- HemagglutininHA proteinInfluenza HA
02
Mechanism of action
Antibodies bind to HA, blocking receptor binding and/or membrane fusion, thus neutralizing the virus.
03
Biological functions
Receptor bindingMembrane fusionViral entryAntigen presentation
04
Disease associations
InfectionInfluenzaViral pathogenesis
05
Safety considerations
Antigenic drift and shift leading to vaccine mismatchPotential for antibody-dependent enhancement (ADE) in some cases
06
Interacting drugs
NA inhibitors (indirectly, by preventing viral release)
1 more in the full profile.
07
Biomarkers
HA titer (for vaccine efficacy)HA sequence (for strain identification and vaccine matching)
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