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Influenza Virus-Infected Cell (via Antibody-Dependent Cellular Cytotoxicity) (Influenza-infected cell (ADCC))

Target: Influenza-infected cell (ADCC)
Molecular classification: Host Cell, Virus-Infected Cell

Overview

An influenza virus-infected cell targeted for destruction through antibody-dependent cellular cytotoxicity (ADCC). Antibodies bind to viral antigens (Hemagglutinin (HA), Neuraminidase (NA), M2 ectodomain) expressed on the surface of infected cells. Effector immune cells (NK cells, monocytes, neutrophils) recognize these antibodies via their Fc receptors and mediate lysis of the infected cell, contributing to protective immunity. ADCC-mediating antibodies often display greater breadth than classic neutralizing Abs because they frequently target conserved regions.

Other names: Influenza infected cell targeted by ADCCADCC-mediated killing of influenza-infected cellsInfluenza virus-infected host cell (ADCC)Antibody-dependent cellular cytotoxicity of influenza-infected cells

Biological functions

Target of immune responseAntigen presentationViral replication (within the cell)

Disease associations

InfectionInfluenzaViral disease

Safety considerations

Excessive tissue damage due to overactivation of ADCCPotential for cytokine storm

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