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Inhibitor of growth family, member 1 pseudogene

Molecular classification
Pseudogene, Non-coding RNA
01

Overview

The Inhibitor of growth family, member 1 pseudogene (ENSG00000223672) is a DNA sequence in the human genome that closely resembles the protein-coding ING1 gene but contains mutations that prevent it from producing a functional protein. Such pseudogenes are generally considered nonfunctional in terms of protein expression, though they may sometimes be transcribed into non-coding RNAs that can regulate the expression of related protein-coding genes through RNA interference pathways or by acting as decoys for regulatory microRNAs. However, there is no evidence that this pseudogene itself is a drug target, receptor, enzyme, or other canonical therapeutic target class[1][2][3][6]. This entry is mainly included in gene databases for annotation and evolutionary purposes and should not be considered a therapeutic target in the conventional sense.

Other names
ING1PING1 pseudogene
02

Biological functions

Possible regulation of parental gene expression via RNA interference (acting as a microRNA decoy or source of small RNAs)No direct protein-coding function; may function as noncoding RNA
03

Disease associations

Potential indirect involvement in cancer or gene regulation through RNA-mediated mechanisms, but not as a direct targetMost pseudogenes not directly implicated as disease targets

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