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Target intelligence / Profile preview
INO80B-WBP1 readthrough (NMD candidate) (INO80B-WBP1)
- Target
- INO80B-WBP1
- Molecular classification
- Non-coding RNA (ncRNA), Readthrough transcript, Not assigned to standard families like receptor, enzyme, transporter, etc.
01
Overview
INO80B-WBP1 is a non-coding RNA locus formed by a naturally occurring readthrough event between the INO80B gene and the downstream WBP1 gene on chromosome 2. This transcript is a candidate for nonsense-mediated decay and does not produce a protein product. It is not classified as a receptor, enzyme, or other typical drug target class. The RNA is thought to arise through transcriptional read-through but is rapidly degraded in cells. There is currently no evidence for its direct involvement in human disease, nor is it the focus of therapeutic targeting or clinical biomarker studies.
- Other names
- INO80B-WBP1INO80 complex subunit BHMGA1L4HMGIYL4IES2PAP-1BPPAPA-1ZNHIT4hIes2PAPA1WW domain-binding protein 1
02
Mechanism of action
Not applicable (no known mechanism for drug interaction)
03
Biological functions
Generally considered to have no direct function due to rapid degradation by NMDMay reflect regulatory genomic events, but specific biological functions remain uncharacterized
04
Disease associations
No established direct roles in diseaseSome evidence that mutations in adjacent INO80B may be associated with developmental abnormalities, but not specifically for the readthrough transcript
05
Safety considerations
None specific
06
Interacting drugs
None
07
Biomarkers
None known for patient selection or efficacy monitoring
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