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Inosine-5'-monophosphate dehydrogenase (None)
- Target
- None
- Molecular classification
- Enzyme, Dehydrogenase
01
Overview
Inosine-5'-monophosphate dehydrogenase (IMPDH) is a key enzyme in purine metabolism, catalyzing the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5'-monophosphate (XMP). This reaction represents the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, which are essential for DNA and RNA synthesis, signal transduction, and energy transfer. IMPDH exists as two isoforms, IMPDH1 and IMPDH2. It is targeted by immunosuppressant and anticancer agents.
02
Mechanism of action
Inhibition of IMPDH, leading to depletion of guanine nucleotides.
03
Biological functions
Guanine nucleotide biosynthesisCell growth regulationNucleic acid bindingReplicationTranscriptionTranslation
04
Disease associations
CancerImmunodeficiency
05
Interacting drugs
Mycophenolic acid
1 more in the full profile.
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