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Inosine-5'-monophosphate dehydrogenase 1 (None)
- Target
- None
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) is an enzyme that catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the rate-limiting step in guanine nucleotide biosynthesis. This enzyme is crucial for regulating cell growth and is a target for immunosuppressive drugs. Mutations in IMPDH1 are associated with retinitis pigmentosa type 10.
- Other names
- IMPDH-IRP10LCA11inosine monophosphate dehydrogenase I
02
Mechanism of action
Inhibition of IMPDH1, leading to depletion of guanine nucleotides
03
Biological functions
Guanine nucleotide biosynthesisCell proliferationDNA synthesisRNA synthesisRegulation of intracellular nucleotide pools
04
Disease associations
Retinitis pigmentosa type 10Malignancy
05
Safety considerations
Potential for immunosuppression (with IMPDH inhibitors)Impact on rapidly dividing cells (potential for toxicity)
06
Interacting drugs
Mycophenolic acid
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