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Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)

Target: IMPDH2
Molecular classification: Enzyme

Overview

Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) is an enzyme that catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate (IMP) to xanthosine-5'-monophosphate (XMP), a key step in guanine nucleotide synthesis. It is essential for maintaining cellular pools of guanine nucleotides required for DNA and RNA synthesis, signal transduction, and energy transfer. IMPDH2 is upregulated in some neoplasms and is a target for immunosuppressive and anticancer agents.

Other names: IMPD2IMPDH-IIInosine monophosphate dehydrogenase 2Inosine 5′-(phosphate) dehydrogenase 2

Mechanism of action

Inhibition of IMPDH2 activity

Biological functions

Guanine nucleotide biosynthesisDNA synthesisRNA synthesisCell growthRegulation of intracellular guanine nucleotide pool

Disease associations

CancerImmunosuppression

Interacting drugs

Immunosuppressive drugs

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