Integrin-collagen fibril complex (Mesenchymal Stem Cell) (MSC Integrin-Collagen Complex)

The interaction between collagen fibrils and integrins on Mesenchymal Stem Cells (MSCs) is a fundamental process governing stem cell behavior within the extracellular matrix (Source: PMID: 22431269). MSCs primarily utilize collagen-binding integrins, such as alpha-1 beta-1, alpha-2 beta-1, and alpha-11 beta-1, to anchor themselves to collagenous scaffolds (Source: PMID: 28811323). This engagement is not merely structural; it initiates mechanotransduction pathways, such as the YAP/TAZ and MAPK/ERK signaling cascades, which dictate whether an MSC remains quiescent, migrates, or differentiates into lineages like osteoblasts or chondrocytes (Source: PMID: 30333243). In pathological states like fibrosis or the tumor microenvironment, this interaction is often dysregulated, leading to excessive myofibroblast activation or cancer progression (Source: PMID: 31601564). Therapeutic targeting of this complex involves small molecules or monoclonal antibodies designed to block the integrin-collagen binding site, thereby modulating MSC recruitment and activity in regenerative medicine or anti-fibrotic applications (Source: PMID: 25605800). However, because these integrins are also expressed on other cell types like platelets, systemic inhibition poses risks such as impaired hemostasis (Source: PMID: 19139250).

Other names

MSC-collagen bindingIntegrin-mediated MSC adhesionCollagen-binding integrins on MSCsVLA-2-collagen interaction

Competitive inhibition of the integrin I-domain or ligand-binding site to prevent collagen fibril engagement and downstream signaling.