Integrin subunit alpha 2 (ITGA2) mRNA (ITGA2 mRNA)

Integrin subunit alpha 2 (ITGA2) mRNA encodes the alpha 2 chain of the alpha2beta1 integrin, a major cell surface receptor for collagen and laminin [1]. This molecule plays a pivotal role in platelet adhesion to the subendothelial matrix, which is essential for hemostasis and thrombus formation [2]. In the context of oncology, ITGA2 mRNA expression is often dysregulated, contributing to the invasive and metastatic potential of cancer cells by modulating cell-extracellular matrix interactions and signaling pathways like PI3K/Akt [3]. Therapeutic targeting of ITGA2 mRNA, such as through the use of the small molecule E-7820 or experimental RNA interference (RNAi) technologies, aims to downregulate the receptor's expression to treat cancer and prevent pathological angiogenesis [4]. Additionally, genetic variations in the ITGA2 gene are associated with risks of cardiovascular diseases and stroke, highlighting its importance as both a therapeutic target and a potential biomarker [5].

Other names

CD49BVLA-2 alpha subunitPlatelet membrane glycoprotein IaGPIaCollagen receptorBRIC256HPA-5

Suppression of mRNA transcription and reduction of cell surface integrin alpha-2 protein levels [4]