Integrin subunit alpha 3 mRNA 3' untranslated region (ITGA3 mRNA 3' UTR)

The Integrin subunit alpha 3 (ITGA3) mRNA 3' untranslated region (UTR) is a critical regulatory segment of the ITGA3 transcript that governs protein expression through post-transcriptional mechanisms (Source: NCBI Gene, 2024). This region contains binding sites for various microRNAs (miRNAs), such as miR-124 and miR-199a-5p, and RNA-binding proteins that influence mRNA stability and translation efficiency (Source: PubMed, PMID: 25600650, PMID: 29393354). In many oncogenic contexts, the loss of miRNA-mediated suppression at this 3' UTR leads to the overexpression of ITGA3, which subsequently promotes cell migration, invasion, and the epithelial-mesenchymal transition (EMT) (Source: PubMed, PMID: 28415645). Consequently, the ITGA3 mRNA 3' UTR is an emerging therapeutic target for RNA-based interventions, such as miRNA mimics or antisense oligonucleotides, aimed at restoring normal regulation and inhibiting tumor progression (Source: PubMed, PMID: 28656238). Research has specifically highlighted its role in breast, lung, and colorectal cancers, where targeting this region can significantly reduce metastatic potential (Source: PubMed, PMID: 29393354).

Other names

ITGA3 3' UTRCD49c mRNA 3' UTRIntegrin alpha 3 3' untranslated regionMSK18 mRNA 3' UTRVLA-3 mRNA 3' UTR

RNA interference and antisense-mediated degradation or translational repression