Integrin subunit beta 8 (ITGB8) mRNA 3' untranslated region (3' UTR) (ITGB8 mRNA 3' UTR)

The Integrin subunit beta 8 (ITGB8) mRNA 3' untranslated region (3' UTR) is a critical regulatory segment of the messenger RNA that encodes the ITGB8 protein. This region contains multiple binding sites for microRNAs (miRNAs), such as miR-199a-5p and miR-145, which post-transcriptionally regulate ITGB8 expression by inducing mRNA degradation or inhibiting translation (PubMed: 28415633, PubMed: 30106614). The ITGB8 protein itself is a member of the integrin family that facilitates the activation of latent transforming growth factor-beta (TGF-beta), a potent cytokine involved in immune suppression, fibrosis, and tumor progression (UniProt: P26012). Dysregulation of the ITGB8 3' UTR, often through the loss of miRNA-mediated control, leads to elevated ITGB8 levels, which is associated with poor prognosis in various cancers, including glioblastoma and lung cancer (PubMed: 25605116). As a therapeutic target, the ITGB8 3' UTR is being explored for the development of RNA-based therapies, including miRNA mimics and antisense oligonucleotides, designed to suppress ITGB8 production and subsequently inhibit TGF-beta-driven pathologies. These approaches aim to provide a more localized or specific modulation of the TGF-beta pathway compared to systemic protein-level inhibitors.

Other names

ITGB8 3'-UTRIntegrin beta-8 3' untranslated regionITGB8 3-prime untranslated region

Post-transcriptional gene silencing via miRNA-mediated mRNA degradation or translational inhibition.