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Intercellular communication via transfer of microRNAs, proteins, and metabolites

Molecular classification
Other
01

Overview

Intercellular communication via transfer of microRNAs, proteins, and metabolites" refers to the collective set of biological processes through which cells release and receive diverse small molecules—including microRNAs (miRNAs), proteins, and metabolites—either through membrane-bound vesicles (such as exosomes, microvesicles, and apoptotic bodies), gap junctions, or carrier complexes. These processes play critical roles in regulating gene expression, modulating immune responses, coordinating development and differentiation, and propagating signals in health and immune responses as well as during disease states such as cancer and inflammation. This is not a single defined molecular entity and therefore is not considered a canonical drug target, but rather a foundational mechanism present in many physiological and pathological processes.

Other names
Extracellular vesicle-mediated communicationExosome-mediated signalingmiRNA intercellular transport
02

Biological functions

Gene expression regulationSignal transductionModulation of cell fate and functionSynchronization of cell responses
03

Disease associations

CancerInflammationCardiovascular diseaseImmune dysfunctionNeurological disease
04

Biomarkers

Circulating extracellular microRNAs serve as emerging biomarkers in various diseases

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