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Intercellular Matrix (Stratum Corneum) (SC Intercellular Matrix)
- Target
- SC Intercellular Matrix
- Molecular classification
- Lipid Matrix, Extracellular Matrix, Lipid Bilayer, Protein Matrix
01
Overview
The intercellular matrix of the stratum corneum is the lipid-rich extracellular material filling the spaces between corneocytes. It is composed primarily of ceramides, cholesterol, and free fatty acids, organized into multilamellar structures. This matrix is crucial for maintaining the skin's barrier function, preventing water loss, and protecting against external insults such as pathogens, toxins, and mechanical stress. Disruption of this matrix leads to skin disorders characterized by impaired barrier function.
- Other names
- Stratum Corneum Lipid MatrixSC Lipid EnvelopeCorneocyte Lipid Lamellae
02
Mechanism of action
Enhancing or repairing the lipid barrier function; reducing transepidermal water loss (TEWL); providing anti-inflammatory effects.
03
Biological functions
Permeability BarrierWater RetentionProtection against PathogensProtection against ToxinsMechanical StrengthRegulates hydration
04
Disease associations
Eczema (Atopic Dermatitis)IchthyosisXerosis (Dry Skin)Contact DermatitisInfection
05
Safety considerations
Potential for allergic reactions to components of emollients or topical medicationsOcclusion can exacerbate some skin conditionsLong-term use of topical corticosteroids can have side effects
06
Interacting drugs
Emollients (e.g., Petrolatum, Mineral Oil)
4 more in the full profile.
07
Biomarkers
Transepidermal Water Loss (TEWL)Skin Hydration LevelsCeramide LevelsFatty Acid Composition
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