Interferon regulatory factor (family) (IRF (family))

Interferon regulatory factor pathway refers to the collective molecular signaling networks mediated by the interferon regulatory factor (IRF) family of transcription factors, which regulate the transcription of type I interferons (IFNs) and interferon-stimulated genes (ISGs), forming a crucial component of innate and adaptive immune responses[1][2][3][4][7]. IRFs function downstream of pathogen recognition receptors such as Toll-like receptors to mediate antiviral defense, cell growth, apoptosis, and cytokine regulation[1][2][4][6]. The pathway encompasses multiple IRFs (IRF1-9 in mammals), each with distinct but sometimes overlapping roles in disease, development, and immunity[2][3]. Defining "interferon regulatory factor pathway" as a therapeutic target is imprecise; drug discovery typically focuses on specific IRFs, such as IRF3 or IRF7, not the entire pathway.

Other names

Interferon regulatory factorsIRF familyIRF proteinsIRF pathway