Interferon regulatory factor 1 (IRF1) mRNA (IRF1 mRNA)

Interferon regulatory factor 1 (IRF1) mRNA is the messenger RNA transcript that encodes the IRF1 protein, a pioneering member of the interferon regulatory factor family. As a transcription factor, IRF1 plays a pivotal role in the innate and adaptive immune systems by regulating the expression of type I and type II interferons (IFNs) and numerous interferon-stimulated genes (ISGs) (UniProt P10914; NIH 1.3.2). It is involved in diverse biological processes, including antiviral defense, cell cycle control, and the induction of apoptosis (UniProt 1.3.3; NIH 1.2.1). In the context of disease, IRF1 acts as a tumor suppressor in many cancers, but its dysregulation is also linked to inflammatory conditions, autoimmune diseases like systemic lupus erythematosus (SLE), and ischemia-reperfusion injury (NIH 1.1.2, 1.3.5). Therapeutic strategies targeting IRF1 mRNA, such as small interfering RNAs (siRNAs) and antisense oligonucleotides (ASOs), aim to modulate its expression to treat these conditions (NIH 1.4.1, 1.4.2). While no IRF1-targeted RNA therapies are currently FDA-approved, they represent a promising approach for targeting transcription factors that are traditionally considered undruggable by small molecules (NIH 1.4.3, 2.3.1).

Other names

IRF-1 mRNAMAR mRNAMyeloid-associated regulatory factor mRNAInterferon regulatory factor 1 transcript

RNA interference-mediated degradation of mRNA and antisense-mediated translational inhibition or RNase H-dependent cleavage.