Interleukin 10 Producing CD4+ T Lymphocyte (IL-10 producing CD4+ T cell)

Interleukin-10 (IL-10) producing CD4+ T lymphocytes are a specialized subset of T cells characterized by their ability to secrete the anti-inflammatory cytokine IL-10. These cells play a crucial role in immune regulation, limiting excessive inflammation and maintaining immune homeostasis. They can arise from various CD4+ T cell lineages, including Th1, Th2, Th17, and regulatory T cells. Their primary function is to suppress excessive inflammatory responses and limit tissue damage during infection, although this suppressive effect may also limit pathogen clearance or anti-tumor immunity.

Other names

IL-10+ CD4+ T cellRegulatory CD4+ T cellTr1-like cellTH1-like regulatory cell

Secretion of IL-10, suppression of APC activation, limitation of proinflammatory cytokine production, dampening of effector responses.