Interleukin-10 receptor subunit alpha (IL10RA) mRNA (IL10RA mRNA)

Interleukin-10 receptor subunit alpha (IL10RA) mRNA is the transcript responsible for the synthesis of the high-affinity subunit of the IL-10 receptor complex. This receptor is essential for the anti-inflammatory signaling of Interleukin-10, which acts to limit the immune response and prevent host tissue damage (UniProt P40189). Upon translation, the IL10RA protein works in tandem with IL10RB to activate the JAK1/STAT3 pathway, effectively inhibiting the production of pro-inflammatory cytokines like TNF-alpha and IL-12 (PubMed: 31553003). Deficiencies or mutations in IL10RA mRNA lead to a loss of this regulatory control, resulting in severe clinical phenotypes such as very early-onset inflammatory bowel disease (VEO-IBD) (PubMed: 20018966). In the context of drug development, IL10RA mRNA is a target for gene-addition or mRNA-replacement therapies designed to restore functional receptor expression in patients with genetic defects. Conversely, modulating its expression via RNA interference is a potential strategy for fine-tuning immune responses in various inflammatory or oncological settings. The primary therapeutic challenge involves the precise delivery of mRNA to target immune cells, such as macrophages, while maintaining a safety profile that avoids systemic immune compromise (PubMed: 25637310).

Other names

IL-10R1 mRNACD210 mRNAInterleukin-10 receptor 1 mRNAIL10R mRNACD210a mRNA

Restoration of functional IL-10 receptor alpha protein through exogenous mRNA delivery or modulation of endogenous mRNA stability and translation to regulate immune homeostasis (PubMed: 31553003).