Interleukin-23 (IL-23) (IL-23)

Interleukin-23 is a heterodimeric cytokine member of the IL-12 family, composed of IL-23p19 and IL-12p40 subunits[4][7][1][8]. It is secreted by activated dendritic cells, macrophages, monocytes, and other immune cells upon stimulation by antigens or pattern recognition receptors[4][8]. IL-23 exerts its biological effects via the IL-23 receptor, which activates the JAK2/TYK2/STAT3 signaling pathway, leading to Th17 cell maintenance and expansion, and release of proinflammatory cytokines crucial for defense against pathogens and the development of mucosal barrier immunity[2][4][8]. Aberrant activation or overproduction of IL-23 drives chronic inflammation and autoimmunity, especially in skin, gut, and joints[2][4][8]. Pharmacologic inhibitors of IL-23 or its receptor represent an important class of therapies for psoriasis, inflammatory bowel disease, and related disorders[2][5][6][8].

Other names

IL-23Interleukin 23IL-23 pathwayIL-23/Th17 axis

Monoclonal antibody blockade of IL-23 (p19 or p40 subunit), blocking IL-23 binding to its receptor and downstream signaling through JAK2/TYK2/STAT3/STAT4 Downregulation of Th17 proliferation and effector cytokine release (IL-17, IL-22, GM-CSF), reducing inflammation Modulation of immune cell trafficking and mucosal barrier function