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Target intelligence / Profile preview
Invariant natural killer T cell receptor (CD1d-restricted)
- Molecular classification
- T cell receptor, Receptor
01
Overview
The invariant natural killer T (iNKT) cell receptor is a unique T cell receptor (TCR) characterized by its restriction to CD1d and its ability to bind glycolipid antigens. In humans, it typically consists of an invariant Vα24-Jα18 paired with Vβ11. iNKT cells recognize glycolipid antigens presented by CD1d, leading to rapid cytokine secretion and influencing immune responses in cancer, infection, autoimmunity, and allergy/inflammation. Modulation of iNKT activity is being explored for immunotherapy.
- Other names
- iNKT cell receptorVα24-Jα18/Vβ11 TCRCD1d-restricted TCR
02
Mechanism of action
Agonist activation via glycolipid binding; modulation of cytokine release
03
Biological functions
Antigen recognitionCytokine secretionCytotoxicityImmune regulationT cell activationInnate immunityAdaptive immunity
04
Disease associations
CancerInfectionAutoimmunityAllergyInflammationTissue homeostasis
05
Safety considerations
Cytokine stormExacerbation of autoimmune diseasesOff-target activation of other immune cellsTumor promotion in certain contexts
06
Interacting drugs
α-galactosylceramide (α-GalCer)
1 more in the full profile.
07
Biomarkers
iNKT cell frequency in blood or tissuesCytokine production profile (IFNγ, IL-4, IL-17, IL-10)CD1d expressionTCR Vα24-Jα18/Vβ11 expression
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